Age And Gender Are Not Factors Of The Condition As Anyone Can Develop It, Though It Often Starts In Adolescence.

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Activating Hair Stem Cells Could Stop Male Pattern Baldness

Then, this new substance can either make its way to the mitochondria where it will make energy or be converted into lactate, another metabolite. "Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly," said study co-author Heather Christofk, associate professor of biological chemistry and molecular and medical pharmacology, in a statement on ScienceDaily . So, in their study on mice, the scientists prevented lactate from being produced, halting stem cell activation. Then they increased lactate in mice, finding that this actually spurred hair growth by activating the stem cell. "Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells," said study co-author William Lowry, a professor of molecular, cell and developmental biology, in a statement. "Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect." Although the scientists did identify two drugs that may help with hair loss, they have not been tested for use in humans and are years away from being prescribed. The new research also might help people diagnosed with alopecia, an autoimmune disease that causes baldness. Age and gender are not factors of the condition as anyone can develop it, though it often starts in adolescence. About 6.8 million Americans have alopecia, according to the National Alopecia Areata Foundation . It starts when the immune systems attacks hair follicles, causing growth to slow, and maybe even stop.

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